So at work I ran into this issue after I installed the most recent Windows 7 updates (including Microsoft Office 2010 updates) – the date up the update was today (Dec 12, 2014).
After the update, I opened my macro enabled workbook in Excel 2010 and basically anything that referenced ActiveX controls (checkboxes, buttons) no longer worked. My auto_open was checking checkboxes and couldn't run… it kept erroring at the first checkbox check. The buttons are also no longer clickable.
Before you say it, I have checked my trust settings and allowed all ActiveX and Macros, but no change. If anyone has any advice, I'm all ears. Due to me not being an admin, I cannot due too many things as far as Windows goes.