The simplest way is an anonymous method passed into Label.Invoke:

// Running on the worker thread
string newText = "abc";
form.Label.Invoke((MethodInvoker)delegate {
    // Running on the UI thread
    form.Label.Text = newText;
});
// Back on the worker thread

Notice that Invoke blocks execution until it completes--this is synchronous code. The question doesn't ask about asynchronous code, but there is lots of content on Stack Overflow about writing asynchronous code when you want to learn about it.

You can extend TextView to set custom fonts as I learned here.

TextViewPlus.java:

package com.example;

import android.content.Context;
import android.content.res.TypedArray;
import android.graphics.Typeface;
import android.util.AttributeSet;
import android.util.Log;
import android.widget.TextView;

public class TextViewPlus extends TextView {
    private static final String TAG = "TextView";

    public TextViewPlus(Context context) {
        super(context);
    }

    public TextViewPlus(Context context, AttributeSet attrs) {
        super(context, attrs);
        setCustomFont(context, attrs);
    }

    public TextViewPlus(Context context, AttributeSet attrs, int defStyle) {
        super(context, attrs, defStyle);
        setCustomFont(context, attrs);
    }

    private void setCustomFont(Context ctx, AttributeSet attrs) {
        TypedArray a = ctx.obtainStyledAttributes(attrs, R.styleable.TextViewPlus);
        String customFont = a.getString(R.styleable.TextViewPlus_customFont);
        setCustomFont(ctx, customFont);
        a.recycle();
    }

    public boolean setCustomFont(Context ctx, String asset) {
        Typeface tf = null;
        try {
        tf = Typeface.createFromAsset(ctx.getAssets(), asset);  
        } catch (Exception e) {
            Log.e(TAG, "Could not get typeface: "+e.getMessage());
            return false;
        }

        setTypeface(tf);  
        return true;
    }

}

attrs.xml: (in res/values)

<?xml version="1.0" encoding="utf-8"?>
<resources>
    <declare-styleable name="TextViewPlus">
        <attr name="customFont" format="string"/>
    </declare-styleable>
</resources>

main.xml:

<?xml version="1.0" encoding="utf-8"?>
<LinearLayout 
    xmlns:android="http://schemas.android.com/apk/res/android"
    xmlns:foo="http://schemas.android.com/apk/res/com.example"
    android:orientation="vertical" android:layout_width="fill_parent"
    android:layout_height="fill_parent">

    <com.example.TextViewPlus
        android:id="@+id/textViewPlus1"
        android:layout_height="match_parent"
        android:layout_width="match_parent"
        android:text="@string/showingOffTheNewTypeface"
        foo:customFont="saxmono.ttf">
    </com.example.TextViewPlus>
</LinearLayout>

You would put "saxmono.ttf" in the assets folder.

UPDATE 8/1/13

There are serious memory concerns with this method. See chedabob's comment below.